神经生物学系
齐洁玉 （系主任）/教授/博士生导师
齐洁玉，js3845金沙线路，院长助理，神经生物学系主任，教授，博士生导师
联系方式：qijieyu@bit.edu.cn
招生方向：基因治疗/AAV/人工智能/分子生物学/干细胞/生物信息
欢迎具有生物学、医学、生物信息学、计算机科学背景的同学加入！
1、个人简介
齐洁玉，1989年10月出生，教授，博士生导师。2025年入选国家级青年人才计划，2024年入选省优青，2020年入选国家“博新计划”。长期致力于遗传性聋的致病机制和内耳基因治疗研究，以一作或通讯作者身份在Lancet，Nature Medicine，Science Advances，Nature Communications（3篇）等有国际影响力的学术期刊。
2、招生专业
生物学、生物技术与工程
3、教育背景
2013.09-2020.03：博士，东南大学，生物学
2009.09-2013.07：学士，南阳师范学院，生物科学
4、工作经历
2024.04至今：北京理工大学，js3845金沙线路，教授，院长助理，神经生物学系主任
2020.04-2024.03：东南大学，生命科学与技术学院，至善博士后，
5、研究领域和方向
以临床耳聋患者治疗需求为导向，聚焦于耳聋发病机制和基因治疗研发与临床应用，打通基因治疗中所用的AAV核酸药物研发、产业化设计、工艺生产、安全评估等通路，建立产学研发展新模式。主要研究内容包括：
（1）探究耳聋致病机制，寻找耳聋精准基因治疗的潜在靶点；
（2）内耳新型转基因递送载体筛选；
（3）开展基因治疗恢复耳聋的基础研究、临床转化研究和临床研究，研发临床可用的耳聋基因治疗药物。
6、获得荣誉
(1) 重庆市科技进步奖一等奖（2025年）
(2) 山东省科技进步奖一等奖（2025年）
(3) 江苏省科学技术奖一等奖（2024年）
(4) 华夏医学科技奖一等奖（2024年）
(5) 中华医学会医学科技奖二等奖（2023年）
(6) 2023年度江苏省行业领域十大科技进展（2024年）
7、承担项目
(1) 广东省科技创新战略专项资金，基础与应用基础研究重大项目（基石），2025B0303000009，干细胞移植联合人工耳蜗植入重建听力的研究，2025/09-2030/08，500万，在研，主持。
(2) 北京市自然科学基金，面上项目，7252089，基因替代疗法挽救隐形遗传性耳聋DFNB1的研究，2025/01-2027/12，20万，在研，主持。
(3) 国家自然科学基金，面上项目，82371162，AAV介导的Cx1、Rassf2、Sparcl1和Atoh1协同调控再生功能性毛细胞的作用和机制研究，2024/01-2027/12，49万，在研，主持。
(4) 国家自然科学基金，联合基金重点支持项目，U23A200440，协同调控毛细胞和螺旋神经元功能性再生修复受损听觉功能的研究，2024/01/01-2027/12/31，130万/260万，在研，子单位负责人。
(5) 科技部科技创新2030-“脑科学与类脑研究”重大项目，2021ZD0205400，听觉机械转导通道复合物的组装机制及功能研究，2022/01-2026/12，150万/500万，在研，子课题负责人。
(6) 国家自然科学基金，青年项目，82000984，AAV介导GPA，Espin和DKK3协同调控内耳干细胞再生为功能性毛细胞的研究，2021/01-2023/12，24万，结题，主持。
(7) 人力资源和社会保障部、全国博士后管委会，创新人才项目，BX20200082，2020年度博士后创新人才支持计划，2020/07-2022/06，63万，结题，主持。
(8) 中国博士后科学基金，面上项目，2020M681468，耳聋基因Tprn的致聋分子机制及AAV-Tprn介导的基因治疗，2020/12-2022/11，8万，结题，主持。
(9) 科技部国家重点研发计划项目“干细胞及转化研究”重点专项，青年项目，2020YFA0113600，通过三维导电生物材料和电刺激调控神经干细胞构建体外类脑与内耳器官的研究，2020/10-2024/12，135.25万/541万，结题，子课题负责人。
(10) 江苏省博士后科研资助计划，2021/05-2023/05，21万，结题，主持。
8、学术兼职
(1) 《Neuroscience Bulletin》青年编委，2026.01-2030.12
(2) 《Flavour and Fragrance Journal》编委，2024.09-2027.08
(3) 《Sensory Neuroscience》青年编委，2024.04-至今
(4) 中国生物物理学会听觉，言语和交流分会，副秘书长，2025.09-2029.08
(5) 中国妇幼保健协会母胎医学分会，常务委员，2025.11-2029.10
(6) 中国生物物理学会听觉，言语和交流分会，青年分会，秘书，2021.08-2025.08
(7) 江苏省发育生物学会听觉科学专委会副秘书长，常务委员，2023.01.05-2027.01.04
(8) 江苏省研究型医院学会青年科学家分会，委员，2021.12-2025.12
9、发表论文：
(1) Jieyu Qi#（第一作者）, Liyan Zhang#, Ling Lu#, Fangzhi Tan#, Cheng Cheng#, Yicheng Lu#, WenXiu Dong, Yinyi Zhou, Xiaolong Fu, Lulu Jiang, Chang Tan, Shanzhong Zhang, Sijie Sun, Huaien Song, Maoli Duan*, Dingjun Zha*, Yu Sun*, Xia Gao*, Lei Xu*, Fan-Gang Zeng*, Renjie Chai*. AAV gene therapy for autosomal recessive deafness 9: a single-arm trial. Nature Medicine, 2025 Sep; 31, 2917–2926. (IF: 50.0) 一区（ESI高被引论文）
(2) Jieyu Qi（唯一第一作者）, Lei Xu, Fan-gang Zeng, Renjie Chai*, OTOF-related gene therapy: a new way but a long road ahead. Lancet, 2025 Mar 8;405(10481):777-779. (IF: 88.5)一区
(3) Liyan Zhang#, Yicheng Lu#, Xianmin Wu#, Jinyi Fan#, Xinru Zhang#, Yang Xu#, Hao Wei, Qiuhan Sun, Lulu Jiang, Huawei Tuo, Nianci Li, Hua Jin, Wu Cao, Beibei Ye, Ziyu Zhang, Yunkai Zhang, Fangyi Chen, Ling Lu*, Jieyu Qi*（并列通讯作者）, Renjie Chai*, Fangzhi Tan*. Human Promoter-Driven AAV Tools Enable Precision Gene Therapy Targeting Cochlear Hair Cells. Cell Reports Medicine. 2026, in press. (IF: 10.8) 一区
(4) Xin Chen#, Yuwei Che#, Jieyu Qi#（并列第一作者）, Ming Cen#, Shan Gao#, Bin Zhu, Yiheng Ao, Xiangyu Ma, Cheng Cheng, Rongrong Guo, Xinlin Wang, Tian Shen, Jiheng Wu, Fanliang Kong, Wei Si, Yongchang Chen, Tao Tan, LingLu*, Renjie Chai*. Molecular heterogeneity of the non-human primate cochlea. Nature Communications, 2026 Jan 17;17(1):1633. (IF: 15.7) 一区
(5) Ziyu Zhang#, Man Wang#, Fangzhi Tan#, Liyan Zhang#, Xiaohan Wang, Xiangyan Chen, Jia Han, Nianci Li, Qiuhan Sun, Yicheng Lu, Zhiping Cui, Zuhong He*, Jieyu Qi*（并列通讯作者）, Renjie Chai*. Precise and efficient DNA base editing restores normal hearing in adult DFNB9 mouse model. Med, 2025 27:101001. (IF: 11.8) 一区
(6) Man Wang#, Ziyu Zhang#, Xiaohan Wang#, Liyan Zhang#, Xiangyan Chen, Nianci Li, Qiuhan Sun, Yicheng Lu, Zuhong He, Hongbo Yang*, Fangzhi Tan*, Jieyu Qi*（并列通讯作者）, Renjie Chai*. Optimized in vivo base editing restores auditory function in a DFNA15 mouse model of deafness. Nature Communications, 2025 Sep 18;16(1):8322. (IF: 15.7) 一区
(7) Nianci Li#, Ziyu Zhang#, Liyan Zhang#, Danqi Wu#, Zhe Li#, Changling Xu, Qiuhan Sun, Yicheng Lu, Yinyi Zhou, Xiaoyun Qian, Yangnan Hu*, Fangzhi Tan*, Jieyu Qi*（并列通讯作者）, Renjie Chai*. Establishment of a cochlear organoid platform for remodeling the extracellular matrix. ACS Nano, 2025 Jul 29;19(29):26542-26561. (IF: 16.1) 一区
(8) Jiaming Li, Mengmeng Jiang, Qiaoran Wang, Zikai Zheng, Jianghua Shen, Jingyi Li, Muzhao Xiong, Yandong Zheng, Xiaoyong Lu, Yusheng Cai, Yanling Fan, Lingling Geng, Qianzhao Ji, Qianqian Peng, Shuhui Sun, Yuanyuan Wang, Zijuan Xin, Kaowen Yan, Yuanhan Yang, Jun Yu, Haoteng Yan, Ding Ai*,……, Jieyu Qi*（并列通讯作者）, …… Guanghui Liu. The X-Age Project to Construct a Chinese Aging Clock. Nature Aging, 2025 Sep;5(9):1669-1685. (IF: 19.5) 一区
(9) Zeming Wu , Jing Qu , Weiqi Zhang , ……, Jieyu Qi*（并列通讯作者）, …… Guanghui Liu. Biomarkers of ageing of humans and non-human primates. Nat Rev Mol Cell Biol. 2025 Nov;26(11):826-847. doi: 10.1038/s41580-025-00883-8. (IF: 90.2) 一区
(10) Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi*（唯一通讯作者）. The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges. Advanced Science. 2025 Mar 24:e2410494. (IF: 14.1)一区
(11) Nianci Li#, Fangzhi Tan#, Liyan Zhang#, Xiaoqiong Ding#, Qiuhan Sun, Man Wang, Ziyu Zhang, Yicheng Lu, Yinyi Zhou, Xiaoyun Qian, Fanglei Ye*, Jieyu Qi*（并列通讯作者）, Renjie Chai*. AAV-Sparcl1 Promotes Hair Cell Regeneration By Increasing Supporting Cell Plasticity. Molecular Therapy, 2025 Jul 2;33(7):3022-3035. (IF: 12) 一区
(12) Jieyu Qi#（第一作者）, Liyan Zhang#, Yicheng Lu#, Renjie Chai*. Targeting NLRP3/caspase-1/GSDMD to treat inner ear injury from labyrinthine hemorrhage. Molecular Therapy, 33:10, P4684-4685, 2025. 10.1016/j.ymthe.2025.07.052 (IF:12) 一区
(13) Fangzhi Tan#,*, Yue Dong#, Jieyu Qi#（并列第一作者）, Wenwu Yu*, Renjie Chai*. Artificial Intelligence-Based Approaches for AAV Vector Engineering. Advanced Science, 2025 Mar;12(9):e2411062. (IF:14.1)
(14) Fan-Gang Zeng*, Jieyu Qi*（并列通讯作者）, Chen-Chi Wu*, Yilai Shu*, Renjie Chai*. Treating Hearing Loss: From Cochlear Implantation to Gene Therapy. Advanced Science, 2025 Nov;12(41):e09960 (IF:14.1)
(15) Qiuhan Sun#, Fangzhi Tan#*, Liyan Zhang#, Yicheng Lu#, Hao Wei#, Nianci Li, Lulu Jiang, Yinyi Zhou, Tian Chen, Ling Lu*, Genglin Li*, Jieyu Qi*（并列通讯作者）, Shiming Yang*, Renjie Chai*, Combined AAV-mediated specific Gjb2 expression restores hearing in DFNB1 mouse models. Molecular Therapy, 2025 Mar 22:S1525-0016(25)00203-5. (IF: 12)一区
(16) Qiuhan Sun#, Fangzhi Tan#, Xinlin Wang#, Xingliang Gu#, Xin Chen#, Yicheng Lu, Nianci Li, Xiaoyun Qian, Yinyi Zhou, Ziyu Zhang, Man Wang, Liyan Zhang*, Busheng Tong, Jieyu Qi*（并列通讯作者）, Renjie Chai*, AAV-regulated Serpine2 overexpression promotes hair cell regeneration. Molecular Therapy Nucleic Acids, 2024 Nov; 17;35(4):102396. (IF: 6.5) 一区
(17) Liyan Zhang#, Fangzhi Tan#, Jieyu Qi#（并列第一作者）, Yicheng Lu#, Xiaohan Wang, XuehanYang, Xiangyan Chen,Xinru Zhang, Jinyi Fan, Yinyi Zhou, Li Peng, Nianci Li, Lei Xu,* Shiming Yang,* Renjie Chai*. AAV-mediated Gene Therapy for Hereditary Deafness: Progress and Perspectives. Advanced Science, 2024 Nov; 18:e2402166. (IF:14.1) 一区
(18) Xiangyu Ma#, Xin Chen#, Yuwei Che#, Siyao Zhu#, Xinlin Wang, Shan Gao, Jiheng Wu, Fanliang Kong, Cheng Cheng, Yunhao Wu, Jiamin Guo, Jieyu Qi*（并列通讯作者）, Renjie Chai, A Single-cell Transcriptomic Landscape of the Topological Differences in Mammalian Auditory Receptor, Science China-Life Science, 2024 Nov;67(11):2398-2410. (IF:8) 二区
(19) Liyan Zhang#, Xin Chen#, Xinlin Wang#, Yinyi Zhou#, Yuan Fang#, Xingliang Gu, Ziyu Zhang, Qiuhan Sun, Nianci Li , Lei Xu*, Fangzhi Tan*, Renjie Chai*, Jieyu Qi*（最后并列通讯作者）. AAV-mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration. Advanced Science, 2024, Aug;11(29):e2304551. (IF:14.1) 一区
(20) Jieyu Qi#（第一作者）, Liyan Zhang#, Renjie Chai. AAV-based gene replacement: The promise of gene therapy for deafness. Molecular Therapy Nucleic Acids, 2024, 2024 Apr 11;35(2):102181. doi: 10.1016/j.omtn.2024.102181. (IF: 6.5)
(21) Changling Xu#, Liyan Zhang#, Yinyi Zhou#, Haoliang Du#, Jieyu Qi#（并列第一作者）, Fangzhi Tan#, Li Peng, Xingliang Gu, Nianci Li, Qiuhan Sun, Ziyu Zhang, Yicheng Lu, Xiaoyun Qian, Busheng Tong*, Jiaqiang Sun*, Renjie Chai*, Yi Shi*. Pcolce2 overexpression promotes supporting cell reprogramming in the neonatal mouse cochlea. 2024, Cell Proliferation, 2024 Mar 25:e13633. (IF: 5.6) 一区
(22) Jieyu Qi#（第一作者），Fangzhi Tan#，Liyan Zhang#，Ling Lu#，Hongyang Wang#，Wenyan Li，Wenwen Liu，Xiaolong Fu，Zuhong He，Xiaoqiong Ding，Shan Sun，Qiaojun Fang，Yaodong Dong，Xuewei Zhu，Busheng Tong，Xianbao Cao，Min Guo，Xinmiao Fan，Qin Wang，Lu Ma，Tianhong Zhang29，Yafeng Yu，Yongxin Li，Jiangang Fan，Yong Cui，Peina Wu，Hongzheng Zhang，Jie Tang, Weiwei Guo，Dingjun Zha，Fanglei Ye，Shuangba He，Wei Cao, Jianming Yang, Xiaoyun Qian，Yu Zhao，Jingwu Sun，Xiaowei Chen，Yu Sun，Ming Xia，Qiuju Wang，Huijun Yuan，Yong Feng，Weijia Kong，Shiming Yang，Haibo Wang，Maoli Duan*, Xia Gao*，Huawei Li*，Lei Xu*，Renjie Chai*, Clinical practice guidelines for gene therapy to treat hereditary hearing loss. Interdisciplinary Medicine, 2024 Mar 2(2): e20240008. (IF:13.6)
(23) Qiuhan Sun#, Liyan Zhang#, Tian Chen#, Nianci Li#, Fangzhi Tan#*, Xingliang Gu, Yinyi Zhou, Ziyu Zhang, Yicheng Lu, Jie Lu, Xiaoyun Qian, Bing Guan*, Jieyu Qi*（并列通讯作者）, Fanglei Ye* Renjie Chai*. AAV-mediated Gpm6b expression supports hair cell reprogramming. Cell Proliferation, 2024 Jul; 57(7):e13620. (IF: 5.6) 一区
(24) Jieyu Qi#（第一作者）, Fangzhi Tan#, Liyan Zhang#, Ling Lu#, Shanzhong Zhang#, Yabo Zhai#, Yicheng Lu#, Xiaoyun Qian#, WenXiu Dong, Yinyi Zhou, Ziyu Zhang, Xuehan Yang, Lulu Jiang, Chaorong Yu, Jiancheng Liu, Tian Chen, Lianqiu Wu, Chang Tan, Sijie Sun, Huaien Song, Yilai Shu*, Lei Xu*, Xia Gao*, Huawei Li*, Renjie Chai*. AAV-Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness. Advanced Science, 2024 Jan 8: e2306788. (IF:14.1) （ESI高被引论文）
(25) Jieyu Qi#,*（第一作者，并列通讯作者）, Liyan Zhang#, Fangzhi Tan#,*, Yang Zhang#, Yinyi Zhou, Ziyu Zhang, Hongyang Wang, Chaorong Yu, Lulu Jiang, Jiancheng Liu, Tian Chen, Lianqiu Wu, Shanzhong Zhang, Sijie Sun, Shan Sun*, Ling Lu*, Qiuju Wang*, Renjie Chai*. Pre-clinical efficacy and safety evaluation of AAV-OTOF in DFNB9 mouse model and non-human primate. Advanced Science, 2024 Jan;11(3):e2306201. Epub 2023 Nov 28. (IF:14.1)
(26) Jieyu Qi#,*（第一作者，并列通讯作者）, Fangzhi Tan#,*, Liyan Zhang#,Yinyi Zhou, Ziyu zhang, Qiuhan Sun, Nianci Li, Yuan Fang, Xin Chen, Yunhao Wu, Guisheng Zhong*, Renjie Chai*. Critical role of TPRN rings in the stereocilia for hearing. Molecular Therapy, 2024, Jan 3;32(1):204-217. Epub 2023 Nov 11. (IF: 12)
(27) Jieyu Qi#（第一作者）, Liyan Zhang#, Xiaohan Wang, Xin Chen, Yiyuan Li, Tian Wang*, Peina Wu*, Renjie Chai*. Modeling, applications and challenges of inner ear organoid, Smart Medicine, 2024 Feb; 3(1): e20230028. First published: 16 January 2024 (IF: 11.6)
(28) Jieyu Qi#（第一作者）, Wenjuan Huang#, Yicheng Lu, Xuehan Yang, Yinyi Zhou, Tian Chen, Xiaohan Wang, Yafeng Yu*, Jia-Qiang Sun*, Renjie Chai*. Stem cell-based hair cell regeneration and therapy in the inner ear. Neuroscience Bulletin, 2024 Jan;40(1):113-126. Epub 2023 Oct 3. (IF: 5.9)
(29) Liyan Zhang#, Jieyu Qi1#,*（并列一作和并列通讯作者）, Yuan Fang#, Fangzhi Tan#, Ziyu Zhang, Yinyi Zhou, Yideng Huang*, Jingwu Sun*, Renjie Chai*,. Rassf2 overexpression mediated by AAV promotes the supporting cell-to-hair cell transformation in the cochlea. Engineered Regeneration, 2023, 4(3): 304-315. Epub 2023 Apr 24. (IF: 0)
(30) Jie Zhao#, Hong Fu#, Jingjing Yu#, Weiqi Hong#, Xiaowen Tian#, Jieyu Qi#（并列第一作者）, Suyue Sun, Chang Zhao, Chao Wu, Zheng Xu, Lin Cheng, Renjie Chai*, Wei Yan*, Xiawei Wei, Zhenhua Shao*. Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine. Nature Communications. 14(1):962, 2023. Published online 2023 Feb 21. (IF: 14.7)
(31) Xuechun Yang#, Jieyu Qi#,*（并列一作和并列通讯作者）, Liyan Zhang#, Fangzhi Tan#, Hongming, Huang, Chunlai Xu, Renjie Chai*, Yong Cui*, Peina Wu*. The role of Espin in the stereocilia regeneration and protection in Atoh1-overexpressed cochlear epithelium. Cell Proliferation, 2023, 56(11): e13483. Epub 2023 Apr 21. (IF: 5.9)
(32) Changling Xu#, Jieyu Qi#,*（并列一作和并列通讯作者）, Xiaojie Hu#, Liyan Zhang#, Qiuhan Sun, Nianci Li, Xin Chen, Fangfang Guo, Peina Wu*, Yi Shi*, Renjie Chai*, Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea. Cell Proliferation, 2023, 56(5); e13458. Epub 2023 Mar 28. (IF: 5.9)
(33) Liyan Zhang#, Yuan Fang#, Fangzhi Tan#, Fangfang Guo#, Ziyu Zhang, Nianci Li, Qiuhan Sun, Jieyu Qi*（并列通讯作者）, Renjie Chai*. AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea. Cellular and Molecular Life Sciences, 2023, 80(4):86. Published: 14 March 2023. (IF: 6.2)
(34) Cheng Cheng#, Jieyu Qi#（并列第一作者）, Liyan Zhang#, He Li#, Jie Lu, Siyu Li, Zhong Zhang, Yue Qiu, Chen Zhang, Xia Gao*, Phillip I Bird*, Renjie Chai*. Absence of Serpinb6a Causes Progressive Hair Cell Apoptosis and Hearing Loss in Mice. Journal of Genetics and Genomics, 50(2), 126-129, 2023. Available online 8 September 2022, Version of Record 23 February 2023 (IF: 5.9)
(35) Jieyu Qi#（第一作者）, Xiaolong Fu#, Liyan Zhang#, Fangzhi Tan#, Nianci Li, Qiuhan Sun, Xiaojie Hu, Lulu Jiang, Zuhong He*, Ming Xia*, Renjie Chai*. Current AAV-mediated gene therapy in sensorineural hearing loss. Fundamental Research. In Press, 2022. Available online 7 September 2022 (IF: 6.2) (国自然基金委官方杂志)
(36) Guodong Hong#, Xiaolong Fu#, Jieyu Qi#（并列第一作者）, Buwei Shao#, Xuan Han, Yuan Fang, Shuang Liu, Cheng Cheng,Chengwen Zhu, Junyan Gao, Xia Gao, Jie Chen*, Ming Xia*, Wei Xiong*, Renjie Chai*. Dock4 Is Required for the Maintenance of Cochlear Hair Cells and Hearing Function. Fundamental Research, 3(4): 557-569, 2022. Available online 29 April 2022, Version of Record 21 July 2023. (IF:6.2) (国自然基金委官方杂志)
(37) Jieyu Qi#（第一作者）, Yan Liu#, Cenfeng Chu, Xin Chen, Weijie Zhu, Yilai Shu, Shuijin He*, Renjie Chai*, Guisheng Zhong*. A cytoskeleton structure revealed by super-resolution fluorescence imaging in inner ear hair cells. Cell Discovery, 5:12, 2019. 2019年2月19日 (IF: 6.255)
(38) Fangzhi Tan#*, Cenfeng Chu#, Jieyu Qi#（并列第一作者）, Wenyan Li#, Dan You, Ke Li, Xing Chen, Weidong Zhao, Cheng Cheng, Xiaoyi Liu, Yunbo Qiao, Bing Su, Shuijin He, Chao Zhong, Huawei Li*, Renjie Chai*, Guisheng Zhong*. AAV-ie enables safe and efficient gene transfer to inner ear cells. Nature Communications, 10(1):3733, 2019. 2019 Aug 19. (IF: 12.121)
(39) Yan Liu#, Jieyu Qi#（并列第一作者）, Xin Chen#, Mingliang Tang#, Cenfeng Chu, Weijie Zhu, Hui Li, Cuiping Tian, Guang Yang, Chao Zhong, Zhang Ying, Guangjian Ni, Shuijin He*, Renjie Chai*, Guisheng Zhong*. Critical role of spectrin in hearing development and deafness. Science Advances, 2019, 5(4): eaav7803. 2019 Apr 17. (IF: 13.116)